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Diastereoselective synthesis of piperazines by manganese-mediated reductive cyclization
Gregory J Mercer1, Matthew S Sigman
1Department of Chemistry, University of Utah, 315 S. 1400 East, Salt Lake City, UT 84112-8500, USA.
Organic Letters
|April 26, 2003
Abstract:
A simple and effective synthesis of trans aryl-substituted piperazines using a Brønsted acid and manganese(0) is described. [reaction: see text]