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Phenolic compounds from Nymphaea odorata.

Zhizhen Zhang1, Hala N ElSohly, Xing-Cong Li

  • 1National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, and Department of Pharmacology, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA.

Journal of Natural Products
|April 26, 2003
PubMed
Summary
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Researchers identified new and known compounds from Nymphaea odorata, including two lignans and six flavonol glycosides. Three compounds (afzelin, quercetin, and myricitrin) showed marginal inhibitory effects against fatty acid synthase.

Area of Science:

  • Phytochemistry
  • Natural Products Chemistry
  • Pharmacognosy

Background:

  • Nymphaea odorata (water lily) is a plant with a history of traditional medicinal use.
  • Phytochemical investigation of medicinal plants is crucial for discovering novel bioactive compounds.
  • Flavonol glycosides and lignans are classes of natural products with diverse biological activities.

Purpose of the Study:

  • To isolate and characterize chemical constituents from the ethanol extract of Nymphaea odorata.
  • To evaluate the inhibitory potential of isolated compounds against fatty acid synthase.

Main Methods:

  • Phytochemical analysis involving assay-guided fractionation of the plant extract.
  • Structure elucidation using comprehensive spectroscopic techniques (e.g., NMR, MS).

Related Experiment Videos

  • In vitro assay to determine the inhibitory activity against fatty acid synthase (FAS).

    • Main Results:

    • Two lignans, including a new compound (nymphaeoside A), and six known flavonol glycosides were identified.
    • The known compounds include afzelin, quercetin 3-O-alpha-l-rhamnopyranoside, myricitrin, and others.
    • Compounds afzelin (3), quercetin 3-O-alpha-l-rhamnopyranoside (4), and myricitrin (7) exhibited marginal inhibitory effects on fatty acid synthase.

    Conclusions:

    • The study successfully identified novel and known compounds from Nymphaea odorata.
    • Specific flavonol glycosides demonstrated preliminary inhibitory activity against fatty acid synthase, suggesting potential therapeutic applications.
    • Further research may explore the structure-activity relationships and optimize the inhibitory potential of these compounds.