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Trisphaerolide A, a novel polyketide from the Dominican sponge Erylus trisphaerus
Ian van Altena1, Rob van Soest, Michel Roberge
1Department of Chemistry and Earth & Ocean Sciences, University of British Columbia, Vancouver, B.C., Canada, V6T 1Z1.
Journal of Natural Products
|April 26, 2003
Abstract:
The structure of trisphaerolide A (1), a mildly cytotoxic metabolite isolated from extracts of the marine sponge Erylus trisphaerus collected in Dominica, has been elucidated by detailed analysis of spectroscopic data. Trisphaerolide A (1) has a putative polyketide biogenesis, incorporating a rare variant on the standard pathway, which involves the addition of methyl branches arising from C-2 carbons of acetate units to chain carbons that arise from C-1 of acetate units.