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Related Experiment Videos

Exercise training improves ageing-induced decrease in eNOS expression of the aorta.

T Tanabe1, S Maeda, T Miyauchi

  • 1Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Acta Physiologica Scandinavica
|April 26, 2003
PubMed
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Exercise training can reverse age-related decreases in aortic endothelial nitric oxide synthase (eNOS) production in rats. This finding suggests exercise may benefit the aging cardiovascular system by restoring eNOS levels.

Area of Science:

  • Cardiovascular Physiology
  • Aging Research
  • Exercise Science

Background:

  • Aging impairs endothelial function, reducing nitric oxide (NO) release and vascular tone.
  • Endothelial NO synthase (eNOS) expression is crucial for NO production.
  • Previous studies showed exercise increases eNOS in young rats, but its effect in aged rats is unknown.

Purpose of the Study:

  • To investigate the effect of exercise training on eNOS mRNA and protein expression in the aorta of aged rats.
  • To determine if exercise can counteract age-related decline in eNOS.

Main Methods:

  • Comparison of three groups: sedentary young rats, sedentary aged rats, and aged rats undergoing 8 weeks of swimming training.
  • Analysis of eNOS messenger RNA (mRNA) and protein expression in aortic tissue.

Related Experiment Videos

  • Measurement of body weight and citrate synthase activity in muscle.

    • Main Results:

    • Exercise training in aged rats led to lower body weight and higher muscle citrate synthase activity compared to sedentary aged rats.
    • Aortic eNOS mRNA expression was higher in trained aged rats than sedentary aged rats, but lower than young rats.
    • Aortic eNOS protein expression was higher in trained aged rats than sedentary aged rats, and comparable to young rats.

    Conclusions:

    • Aortic eNOS production decreases with age in rats.
    • Exercise training can increase eNOS production in aged rats.
    • Exercise training may offer cardiovascular benefits by improving eNOS levels in the aging aorta.