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Updated: Aug 19, 2026

Procedure for Human Saphenous Veins Ex Vivo Perfusion and External Reinforcement
Published on: October 1, 2014
Experience with femoro-popliteal vein as a conduit for vascular reconstruction in infected fields
C P Gibbons1, C J Ferguson, L J Fligelstone
1Department of Vascular Surgery, Morriston Hospital, Swansea SA6 6NL, UK.
Objective:
to review the outcome of femoro-popliteal vein grafts for arterial reconstruction in the presence of sepsis.
Patients And Methods:
twenty-six patients underwent 27 arterial reconstructions with femoro-popliteal vein in the presence of infection. Five had mycotic aneurysms (3 aortic, 1 iliac and 1 femoral), 21 had prosthetic graft infections (9 aortic, 8 femoro-femoral, 2 axillo-femoral, 1 ilio-femoral and 1 femoral dacron patch) and one underwent superior mesenteric artery reconstruction following ischaemic small bowel perforation.Arterial reconstruction followed debridement of infected tissue, removing any infected graft, povidone iodine washout and appropriate antibiotic cover. Where possible, new grafts were placed in a clean field or wrapped in omentum. Four femoral anastomoses were covered by rectus femoris flaps.
Results:
there was one early postoperative death (4%) and no limb loss. All others remained free from infection with patent grafts at 1 month to 5 years (median 22 months). Three major wound infections healed without exposing the graft. One infarcted rectus femoris flap required removal. Donor limb swelling was transient. Five required percutaneous angioplasty and one underwent open profundaplasty within 3 months.
Conclusion:
femoro-popliteal vein reconstruction with debridement and appropriate antibiotic therapy is recommended for the treatment of arterial or graft infections.
Insights
Femoro-popliteal vein grafts are effective for arterial reconstruction in sepsis, showing no limb loss and sustained graft patency. This approach, combined with debridement and antibiotics, is recommended for infected arterial or graft cases.
Area of Science:
- Vascular Surgery
- Infectious Disease Management
- Graft Reconstruction
Background:
- Sepsis poses significant challenges for arterial reconstruction.
- Infected prosthetic grafts require urgent management.
- Femoro-popliteal vein grafts offer a potential solution in complex cases.
Purpose of the Study:
- To evaluate the outcomes of femoro-popliteal vein grafts used for arterial reconstruction in patients with sepsis.
- To assess the efficacy of this technique in managing infected arterial and prosthetic grafts.
Main Methods:
- Retrospective review of 26 patients undergoing 27 arterial reconstructions using femoro-popliteal vein grafts in the presence of infection.
- Inclusion criteria: mycotic aneurysms, prosthetic graft infections, and one superior mesenteric artery reconstruction.
- Surgical approach involved debridement, graft removal (if applicable), povidone-iodine washout, antibiotics, and graft placement in a clean field or omental wrap.
Main Results:
- One early postoperative death (4%) and no instances of limb loss were recorded.
- Graft patency and freedom from infection were maintained in all surviving patients from 1 month to 5 years (median 22 months).
- Three major wound infections resolved without graft exposure; one rectus femoris flap required removal.
Conclusions:
- Femoro-popliteal vein reconstruction, coupled with thorough debridement and appropriate antibiotic therapy, is a recommended treatment for arterial or graft infections.
- This method demonstrates favorable outcomes in limb salvage and graft survival in septic environments.
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