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Liver dysfunction and polymyalgia rheumatica. A case report.

P Kosolcharoen, G E Magnin

The Journal of Rheumatology

|March 1, 1976

Summary

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Polymyalgia rheumatica can affect the liver, causing elevated alkaline phosphatase. Treatment with low-dose steroids improved liver function in a patient with this condition.

Area of Science:

Rheumatology
Hepatology
Immunology

Background:

Polymyalgia rheumatica (PMR) is a systemic inflammatory condition primarily affecting muscles and joints.
Hepatic involvement in PMR is uncommon but can manifest as liver enzyme abnormalities.

Observation:

A second case report details a patient with PMR exhibiting significantly elevated alkaline phosphatase.
Liver biopsy revealed granuloma formation and portal space lymphocytic infiltration.

Findings:

The patient's elevated alkaline phosphatase normalized with low-dose corticosteroid therapy.
This suggests a potential link between PMR and specific liver pathology.

Implications:

Highlights the importance of considering hepatic dysfunction in polymyalgia rheumatica patients.

Related Experiment Videos

Suggests granulomatous hepatitis may be an underrecognized manifestation of PMR.

Low-dose steroids may be effective in managing PMR-associated liver abnormalities.