Orchestrating nuclear functions: ubiquitin sets the rhythm
Related Experiment Video
Updated: Sep 26, 2026

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
Published on: July 25, 2019
Ingolf Bach1, Heather P Ostendorff
1Zentrum für Molekulare Neurobiologie (ZMNH), Universität Hamburg, Germany. ingolf.bach@zmnh.uni-hamburg.de
Abstract:
The nucleus of the eukaryotic cell must carry out many functions simultaneously. These tasks include ensuring that the cell is continuously supplied with an appropriate, changing set of proteins on its way through cell divisions and differentiation. During these processes, the integrity of the genetic material must be maintained against a constant onslaught of damaging physiological and environmental factors. Fulfilling these complex tasks requires the dynamic integration and synchronization of different nuclear functions. Protein modification by ubiquitin is proving to be a crucial tool for nuclear functioning, and is emerging as a decisive mechanism that enables the concerted regulation of nuclear pathways.
Related Concept Videos
Regulation of Nuclear Protein Sorting
Nuclear Protein Sorting
Proteins targeted to the nucleus carry nuclear localization signals or NLS recognized by import receptors in the cytosol. Similarly, proteins with nuclear export signals are recognized by export receptors. Import and export receptors are...
Covalently Linked Protein Regulators
These groups modify specific amino acids in a protein.
Nuclear Export
NES are of three types- the canonical 10-residue long leucine-rich signal and other...
Nuclear Export of mRNA
Nuclear Export of mRNA

