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Updated: Sep 26, 2026

Sample Preparation in Quartz Crystal Microbalance Measurements of Protein Adsorption and Polymer Mechanics
Published on: January 22, 2020
Evaluation and application of conducting polymer entrapment on quartz crystal microbalance in flow injection
Yung-Chuan Liu1, Chih-Ming Wang, Kuang-Pin Hsiung
1Department of Chemical Engineering, National Chung Hsing University, 402, Taichung, Taiwan, ROC. ycliu@dragon.nchu.edu.tw
Abstract:
An immunosensor employing conducting polymer entrapment (CPE) method to immobilize immuno-protein on the quartz crystal microbalance (QCM) for clinical flow-injection-analysis (FIA) purpose was exploited. By comparing the CPE approach and the conventional physical immobilization (PI) method, a frequency shift of the former was 47% higher than that of the latter when measuring at 0.5 mg/ml human serum albumin antibody concentration. This implied that CPE was a feasible approach for developing QCM-FIA process. An immunoassay of anti-pseudorabies virus antibody in mouse sera further exemplified its practical potential in diagnostic implication.
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