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Updated: Aug 12, 2026

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3
11:10

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Published on: December 28, 2010

Comparison of three kinetic models of HIV-1 infection: implications for optimization of treatment

Sonya J Snedecor1

  • 1Department of Biomathematics, University of California, P O Box 951766, Los Angeles, CA 90095-1766, USA. sncdecor@biomath.medsch.ucla.edu

Journal of Theoretical Biology
|April 26, 2003
PubMed

Clinical markers in the peripheral blood guide the treatment of human immunodeficiency virus type 1 (HIV-1). Likewise, many of the theoretical models developed to simulate infection only incorporate variables in the blood. To test the suitability of blood-only models, three distinct models of HIV infection kinetics are compared: "full model" including latently and actively infected cells and virus in the peripheral blood and lymphoid tissue (LT); "reduced model", including peripheral blood and LT without latent cells; and "blood model" including only actively infected cells and virus in the peripheral blood. Using the same parameter values for all three, qualitative differences are demonstrated between the blood model and its more inclusive counterparts. Additionally, optimization studies show that the reduced and blood models generate progressively lower optimal treatment levels relative to the full model when constant-level treatment is considered. These findings indicate that including the lymphoid tissue and latently infected cells into kinetic models may lead to differing conclusions with regard to optimal treatment and could be useful in guiding therapy even when plasma viral levels are below detectable limits.

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