Search research articles

Search research articles

Related Experiment Videos

Copper in medicine.

George J Brewer¹

¹Department of Human Genetics, University of Michigan Medical School, 5024 Kresge Building II, Ann Arbor, MI 48109-0534, USA. brewergj@umich.edu

Current Opinion in Chemical Biology

|April 26, 2003

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Avoiding Alzheimer's disease: The important causative role of divalent copper ingestion.

Experimental biology and medicine (Maywood, N.J.)·2019

Same author

Summaries of the Micronutrient Symposium of the 2016 Meeting of the American College of Nutrition.

Journal of the American College of Nutrition·2017

Same author

Copper-2 Hypothesis for Causation of the Current Alzheimer's Disease Epidemic Together with Dietary Changes That Enhance the Epidemic.

Chemical research in toxicology·2017

Same author

Reply to B. Meunier's Letter to the Editor Re: Brewer G. J.; Nutrients 2015, 7, 10053-10064.

Nutrients·2016

Same author

Correction: Brewer, G.J. Copper-2 Ingestion, Plus Increased Meat Eating Leading to Increased Copper Absorption, Are Major Factors Behind the Current Epidemic of Alzheimer's Disease. Nutrients 2015, 7(12), 10053-10064.

Nutrients·2016

Same author

Copper-2 Ingestion, Plus Increased Meat Eating Leading to Increased Copper Absorption, Are Major Factors Behind the Current Epidemic of Alzheimer's Disease.

Nutrients·2015

Same journal

Function through shape: An overview of DNA G-quadruplexes in transcriptional regulation.

Current opinion in chemical biology·2026

Same journal

Advances in tools and technologies for multiplexed bioluminescence imaging.

Current opinion in chemical biology·2026

Same journal

High-resolution molecular mapping by expansion-coupled label-free and multimodal imaging.

Current opinion in chemical biology·2026

Same journal

Recent advances in glycoconjugate-based therapeutics.

Current opinion in chemical biology·2026

Same journal

Towards better red emitters for bioimaging: Innovations in rhodamine and cyanine chemistry.

Current opinion in chemical biology·2026

Same journal

Chemigenetic fluorescent biosensors in biological imaging - New trends and advances.

Current opinion in chemical biology·2026

See all related articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Copper plays a role in various diseases. Therapies that lower copper show promise for treating conditions like Alzheimer's disease and reducing inflammation, fibrosis, and blood vessel growth.

Area of Science:

Biochemistry
Pathology
Medical Research

Background:

Copper is implicated as a causative agent in numerous human diseases.
Emerging research highlights copper's multifaceted role in physiological and pathological processes.

Purpose of the Study:

To review recent advancements in understanding copper's role in disease.
To explore the therapeutic potential of copper modulation in various medical conditions.

Main Methods:

Literature review of recent findings on copper's role in disease.
Analysis of studies investigating copper chelation and related therapies.
Examination of genetic and non-genetic copper abnormalities.

Main Results:

Related Experiment Videos

Copper-lowering therapy demonstrates potential for antiangiogenic, antifibrotic, and anti-inflammatory effects.

Evidence suggests a role for copper in Alzheimer's disease amyloid plaque formation.

Successful treatment of an Alzheimer's rodent model using copper chelation has been reported.

New copper-related genes associated with disease causation have been identified.

Conclusions:

Copper modulation represents a promising therapeutic strategy for diverse diseases.
Targeting copper metabolism offers potential avenues for treating neurodegenerative disorders like Alzheimer's disease.
Further research into copper-related genetic abnormalities may uncover new disease mechanisms and therapeutic targets.