Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Definitions of enzyme function for the structural genomics era.

Patricia C Babbitt1

  • 1Department of Biopharmaceutical Sciences, University of California, 513 Parnassus Street, San Francisco, CA 94143-0446, USA. babbitt@cgl.ucsf.edu

Current Opinion in Chemical Biology
|April 26, 2003
PubMed
Summary

Researchers are exploring new ways to describe enzyme function at the molecular level. A novel approach may enhance functional inference for enzyme superfamilies, addressing limitations of the current EC system.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Kinetic and Structural Analysis of Two Linkers in the Tautomerase Superfamily: Analysis and Implications.

Biochemistry·2021
Same author

Parallel molecular mechanisms for enzyme temperature adaptation.

Science (New York, N.Y.)·2021
Same author

A strategy for large-scale comparison of evolutionary- and reaction-based classifications of enzyme function.

Database : the journal of biological databases and curation·2020
Same author

Structural Basis for the Asymmetry of a 4-Oxalocrotonate Tautomerase Trimer.

Biochemistry·2020
Same author

The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens.

Genome biology·2019
Same author

Exploring the sequence, function, and evolutionary space of protein superfamilies using sequence similarity networks and phylogenetic reconstructions.

Methods in enzymology·2019

Area of Science:

  • Biochemistry
  • Enzymology
  • Molecular Biology

Background:

  • The current Enzyme Commission (EC) system faces challenges in describing enzyme function at the molecular level.
  • Accurate functional description is crucial for understanding enzyme superfamilies.

Purpose of the Study:

  • To evaluate the strengths and weaknesses of the existing EC system for enzyme function description.
  • To introduce and assess a new approach for describing enzyme function.
  • To improve functional inference capabilities within enzyme superfamilies.

Main Methods:

  • Review and analysis of the EC system's current methodologies.
  • Development and proposal of a novel framework for enzyme function description.
  • Comparative analysis of the new approach against the EC system.

Related Experiment Videos

Main Results:

  • Identified limitations in the EC system's molecular-level functional descriptions.
  • A new approach shows potential for enhanced functional inference.
  • The proposed method may offer improved capabilities for enzyme superfamilies.

Conclusions:

  • The EC system has limitations in detailing molecular enzyme function.
  • A new descriptive approach offers promise for advancing functional inference.
  • Further research is warranted to validate the proposed method for enzyme superfamilies.