Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Missing genes in metabolic pathways: a comparative genomics approach.

Andrei Osterman1, Ross Overbeek

  • 1Integrated Genomics, Inc., 2201 W. Campbell Park Drive, Chicago, IL 60612, USA. andrei@integreatedgenomics.com

Current Opinion in Chemical Biology
|April 26, 2003
PubMed
Summary

New genome context analysis techniques, including gene clustering and protein fusions, identify functional gene links. These methods, combined with metabolic reconstructions, significantly speed up gene discovery.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tryptophan degradation by intestinal Bacteroides induces anti-tumor immunity and limits melanoma growth.

Cell reports. Medicine·2026
Same author

Tryptophan degradation by intestinal Bacteroides induces anti-tumor immunity and limits melanoma growth.

bioRxiv : the preprint server for biology·2026
Same author

BV-BRC: a unified bacterial and viral bioinformatics resource with expanded functionality and AI integration.

Nucleic acids research·2025
Same author

In vivo manipulation of human gut Bacteroides fitness by abiotic oligosaccharides.

Nature chemical biology·2024
Same author

Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria.

bioRxiv : the preprint server for biology·2024
Same author

Author Correction: A novel antibiotic class targeting the lipopolysaccharide transporter.

Nature·2024

Area of Science:

  • Genomics
  • Bioinformatics
  • Systems Biology

Background:

  • Understanding gene function is crucial for biological research.
  • Identifying functional relationships between genes aids in deciphering complex biological pathways.
  • Traditional methods for gene discovery can be time-consuming and labor-intensive.

Purpose of the Study:

  • To introduce and evaluate novel genome context analysis techniques.
  • To demonstrate the utility of these techniques in inferring functional gene coupling.
  • To show how these methods can accelerate gene discovery when integrated with metabolic reconstructions.

Main Methods:

  • Genome context analysis techniques including chromosomal gene clustering, protein fusions, occurrence profiles, and shared regulatory sites.

Related Experiment Videos

  • Integration of these techniques with metabolic reconstructions.

    • Main Results:

    • The discussed techniques effectively infer functional coupling between genes.
    • The combined approach significantly accelerates the pace of gene discovery.

    Conclusions:

    • Genome context analysis provides powerful tools for understanding gene function.
    • Integrating these computational methods with metabolic data offers a rapid pathway for identifying novel genes and their roles.