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Related Experiment Videos

A study of age-related IgE pathophysiological changes.

Gabriele Di Lorenzo1, Maria Luisa Pacor, Maria Esposito Pellitteri

  • 1Dipartimento di Medicina, Clinica e delle Patologie Emergenti dell'Università degli Studi di Palermo, Via del Vespro 141, 90127, Palermo, Italy. dilo601@unipa.it

Mechanisms of Ageing and Development
|April 26, 2003
PubMed
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This study investigated age-related changes in allergic responses, finding no significant differences in immunoglobulin E (IgE) levels or type 2 cytokine production between young and old adults. The decline in allergy onset with age remains questionable.

Area of Science:

  • Immunology
  • Gerontology
  • Allergy Research

Background:

  • Immunosenescence primarily focuses on T cell decline, yet B cell function and immunoglobulin levels also change with age.
  • Allergic disease incidence and severity appear to decrease in older individuals, possibly due to reduced serum total IgE.
  • Age-related changes in cytokines and soluble factors influencing IgE production are implicated in allergy onset decline.

Purpose of the Study:

  • To investigate the mechanisms behind age-related changes in allergic symptom onset and severity.
  • To evaluate serum immunoglobulin E (IgE) and soluble CD23 (sCD23) levels in young and old adults.
  • To assess in vitro type 2 cytokine production (IL-4, IL-10, IL-13) in response to stimulation.

Main Methods:

  • Compared serum IgE and sCD23 levels in young (20-64 years) and old (70-93 years) individuals.

Related Experiment Videos

  • Measured IL-4, IL-10, and IL-13 production from mitogen-stimulated peripheral blood mononuclear cells.
  • Utilized CAP-system fluorescence immunoassay for total IgE and sandwich ELISA for sCD23.

    • Main Results:

    • No significant differences were found in serum total IgE or sCD23 levels between young and old subjects.
    • Detectable levels of IL-4, IL-10, and IL-13 were observed in both groups after PHA stimulation, with no significant inter-group differences.
    • The study did not find impairment in the afferent (cytokine production) or central (serum IgE/sCD23) branches of allergic responses in the elderly.

    Conclusions:

    • The findings do not support an impairment in type 2 cytokine production or serum IgE/sCD23 levels with aging.
    • Previous research indicated no impairment in the efferent branch of allergic responses in the elderly.
    • It is questionable whether current evidence validates the statement that allergic disease incidence decreases with age.