Related Experiment Video
Updated: Aug 19, 2026

Quantitative 3D In Silico Modeling (q3DISM) of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease
Published on: December 26, 2016
Brain immune responses cognitive decline and dementia: relationship with phenotype expression and genetic background
Federico Licastro1, Martina Chiappelli
1Department of Experimental Pathology, University of Bologna, Via S. Giacomo 14, 40126, Bologna, Italy. licastro@alma.unibo.it
Abstract:
Alzheimer's disease (AD) is a progressive degenerative disease of the brain and the most frequent cause of dementia among elderly. The etiology of AD is still obscure, but genetic and environmental factors appear to play differential roles in the disease. Several evidence suggest that inflammation or altered immune responses may play an important role in this disease. The following topics will be discussed: (1) the association of inflammation with brain degenerative processes in AD; (2) the influence of cytokine gene polymorphism upon the risk of developing AD and/or the age at onset of manifestation clinical dementia; (3) the effects of gene allele variations upon the phenotype of immune molecules in the blood and brain of AD patients; (4) the association of genetic variations in some of this molecules with the progression of the disease and cognitive decline.
More Related Videos
09:38Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
06:46Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage
Published on: August 4, 2018
Related Concept Videos
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Dementia
The progression of dementia is generally gradual.
Alzheimer Disease l: Introduction
Alzheimer Disease ll: Pathophysiology
Dementia l: Introduction