Accumulation of calcium in kidney and decrease of calcium in serum of rats treated with tin chloride

Effect of tin on the kidney calcium and serum calcium concentration was studied in rats intraperitoneally administered with tin chloride. The calcium concentration in kidney was significantly increased by administration of tin (1.0 mg/100 g), and this increase was dose dependent. A significant increase in the level of kidney calcium was not exhibited by the administration of zinc, manganese, or lead. The increased calcium after the administration of tin predominantly accumulated in the cortex of kidney. The administration of tin did not show a significant alteration of sodium and potassium concentration in the kidney. The level of serum calcium was significantly decreased by the administration of tin (2.0 mg/100 g), and this reduction was dose dependent. The decrease of serum calcium by the administration of tin was associated with the accumulation of calcium in the kidney by treatment with tin.