Large summertime influenza A outbreak among tourists in Alaska and the Yukon Territory

Timothy M Uyeki1, Suzanne B Zane, Ulana R Bodnar

  • 1Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. tmu0@cdc.gov

Insights

A large outbreak of acute respiratory illness (ARI) in Alaska and Canada was primarily caused by influenza A (H3N2) viruses. This highlights the need for traveler awareness and year-round influenza surveillance.

Area of Science:

  • Epidemiology
  • Virology
  • Public Health

Background:

  • Large outbreaks of acute respiratory illness (ARI) can significantly impact public health, particularly in regions with high tourist traffic.
  • Summertime outbreaks of influenza are less common but can occur, posing a challenge for surveillance and control.

Purpose of the Study:

  • To investigate a significant summertime outbreak of ARI in Alaska and the Yukon Territory.
  • To identify the causative agent and understand the epidemiology of the outbreak.
  • To assess the role of modern travel in disease transmission.

Main Methods:

  • Conducted surveillance for ARI, influenza-like illness (ILI), and pneumonia across 31 sites (hospitals, clinics, cruise ship infirmaries).
  • Isolated and antigenically characterized influenza viruses from affected individuals.
  • Estimated total ARI cases based on reported data.

Main Results:

  • Identified 5361 cases of ARI, including 2864 ILI and 171 pneumonia cases, predominantly among tourists and tourism workers.
  • Isolated influenza A/Sydney/05/97-like (H3N2) viruses from 41 patients with ILI; no other predominant pathogens were found.
  • Estimated over 33,000 ARI cases occurred during the outbreak, primarily attributed to influenza A (H3N2).

Conclusions:

  • Influenza A (H3N2) was the primary cause of the large summertime ARI outbreak.
  • Modern travel patterns can facilitate the rapid spread of influenza across international borders.
  • Increased healthcare provider and traveler awareness, along with year-round surveillance in certain regions, is recommended.

Related Concept Videos

Influenza01:27

Influenza

Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
Investigation of Disease Outbreaks01:23

Investigation of Disease Outbreaks

Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
Infectious Diseases and Their Occurrence01:28

Infectious Diseases and Their Occurrence

Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...
Vaccinations01:51

Vaccinations

Overview
Yellow Fever01:18

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...
Inhalation Anthrax01:25

Inhalation Anthrax

Anthrax is a zoonotic disease caused by Bacillus anthracis, a Gram-positive, spore-forming bacterium. It primarily affects herbivorous animals but can be transmitted to humans through skin contact, ingestion, or inhalation of spores.Cutaneous anthrax, the most common form, typically results from direct contact with bacterial spores through skin abrasions and is generally less severe. Gastrointestinal anthrax results from eating undercooked or contaminated meat. It affects the mouth, throat, or...