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[Drug-induced seizures].

Lene Ørskov Reuther1, Steffen Thirstrup Pedersen, Anita Mandrup Rønn

  • 1H:S Bispebjerg Hospital, Klinisk Farmakologisk Enhed, og Laegemiddelstyrelsen, Institut for Rationel Farmakoterapi.

Ugeskrift for Laeger
|April 29, 2003
PubMed
Summary
This summary is machine-generated.

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Drug-induced seizures are rare but possible. Certain medications like clozapine and enflurane increase seizure risk, especially in predisposed individuals taking antipsychotics or antidepressants.

Area of Science:

  • Pharmacology
  • Clinical Neurology
  • Drug Safety

Context:

  • Drug-induced seizures are a potential adverse effect of numerous medications.
  • Understanding these risks is crucial for patient safety and clinical practice.

Purpose:

  • To identify drugs associated with epileptic seizures.
  • To differentiate risks in patients predisposed versus not predisposed to seizures.

Summary:

  • Drug-induced seizures are uncommon, but certain drugs elevate risk.
  • Clozapine, enflurane, theophylline, foscarnet, ganciclovir, and ritonavir may increase seizure risk even in non-predisposed individuals.
  • Patients with a predisposition to seizures face a greater risk with conventional antipsychotics, olanzapine, risperidone, bupropion, certain antidepressants, cyclosporin, interferon, corticosteroids, propofol, imipenem, chloroquine, and mefloquine.

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Impact:

  • Informing healthcare professionals about specific drug-related seizure risks.
  • Guiding clinical decisions regarding medication choices and patient monitoring.
  • Emphasizing the importance of reporting suspected drug-induced seizures to regulatory agencies.