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Novel antifungal diketopiperazine from marine fungus
Hee-Guk Byun1, Huiping Zhang, Masami Mochizuki
1Marine Biotechnology Institute Co. Ltd., Shimizu, Shizuoka 424-0037, Japan bhg@netian.com
The Journal of Antibiotics
|April 29, 2003
Abstract:
Marine fungi producing antifungal compounds were screened against Pyricularia oryzae (P. oryzae), and a metabolite of marine fungus M-3 isolated from laver (Porphyra yezoensis) showed potent activity. Novel diketopiperazine (1) was isolated from the culture extracts, and its structure was elucidated by spectroscopic methods. The MIC of 1 against P. oryzae was 0.36 microM.