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Related Experiment Videos

[Long-term efficacy of infant hepatitis B immunization program].

Jian Gong1, Rong-cheng Li, Jin-ye Yang

  • 1Center for Disease Prevention and Control, Guangxi Zhuangzu Autonomous Region, Nanning 530021, China.

Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology
|April 30, 2003
PubMed
Summary

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The universal infant hepatitis B (HB) vaccination program effectively prevents hepatitis B virus (HBV) infection and reduces acute HB incidence in children. Long-term follow-up indicates no need for booster doses within 13 years.

Area of Science:

  • Public Health
  • Immunology
  • Infectious Diseases

Context:

  • Hepatitis B virus (HBV) infection is a significant global health concern, particularly in hyperendemic regions.
  • Universal infant immunization programs are crucial for controlling infectious disease transmission.
  • The study evaluates a long-term infant hepatitis B (HB) immunization program in a high-endemic area.

Purpose:

  • To assess the long-term effectiveness of the infant HB immunization program in preventing HBV infection.
  • To determine the program's impact on the incidence of acute hepatitis B in children.
  • To compare the efficacy of plasma-derived and yeast recombinant HB vaccines.

Summary:

  • The universal infant HB vaccination program, initiated in 1986 without routine maternal screening, demonstrated high protective rates against HBV infection (83.5%–96.6%) and HBsAg positivity (83.5%–96.6%) over 13 years.

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  • Recombinant HB vaccine also showed significant efficacy (78.4%–85.2%) in young children.
  • The incidence of acute hepatitis B in children aged 1–14 years decreased by 91.8% post-program implementation, with no cases reported in vaccinated children.

    • Impact:

    • The infant HB vaccination program is highly effective in controlling HBV infection and reducing acute hepatitis B incidence in children in hyperendemic areas.
    • The findings suggest that booster doses may not be necessary within 13 years of primary immunization.
    • Both plasma-derived and yeast recombinant HB vaccines offer comparable long-term protection.