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[On thyroid phosphatase in human serum (author's transl)]
Klinische Wochenschrift
|April 15, 1976
Summary
Hyperthyroidism can increase alkaline phosphatase levels. Thyroid gland alkaline phosphatase isoenzymes were identified in a patient, contributing to elevated serum enzyme activity.
Area of Science:
- Biochemistry
- Endocrinology
- Clinical enzymology
Background:
- Elevated serum alkaline phosphatase (ALP) is common in hyperthyroidism.
- Isoenzyme analysis can localize the source of increased ALP activity.
- The thyroid gland's contribution to serum ALP in hyperthyroidism is not well-established.
Observation:
- A patient with hyperthyroidism exhibited elevated serum ALP.
- Serum analysis identified a specific alkaline phosphatase isoenzyme originating from the thyroid gland.
- This was confirmed by comparing with thyroid organ extracts.
Findings:
- Thyroid gland alkaline phosphatase isoenzyme was detected in the patient's serum.
- This thyroid-specific isoenzyme contributes to the overall increase in serum ALP activity.
- Other contributing organs include bone, liver, and small intestine.
Implications:
- This finding aids in understanding the biochemical profile of hyperthyroidism.
- Isoenzyme analysis can provide a more precise diagnosis for elevated ALP in endocrine disorders.
- Further research may elucidate the specific role of thyroid ALP in hyperthyroid states.