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Dual-kidney transplants: long-term results
Edward J Alfrey1, Adrienne R Boissy, Susan M Lerner
1Department of Surgery, Penn State University, Hershey, PA 17033, USA. ejalfrey@ psu.edu.
Transplantation
|April 30, 2003
Summary
Dual-kidney transplants offer excellent long-term survival. Minimizing cold storage time and avoiding delayed graft function (DGF) are crucial for successful outcomes in kidney transplantation.
Area of Science:
- Nephrology
- Transplantation Surgery
- Immunology
Background:
- Dual-kidney transplantation addresses organ shortage by using two kidneys per recipient.
- The Dual Kidney Registry collects data to analyze outcomes of this procedure.
Purpose of the Study:
- To analyze donor and recipient data and outcomes in dual-kidney transplantation.
- To identify factors influencing graft survival in dual-kidney transplant recipients.
Main Methods:
- A relational database was established with data from 287 dual-kidney transplant recipients since 1994.
- Patients were followed annually, with graft survival and delayed graft function (DGF) as key metrics.
Main Results:
- Mean donor age was 58 years; mean creatinine clearance was 77 mL/min.
- Delayed graft function (DGF), occurring in 27% of recipients, was linked to longer cold storage times and predicted poorer outcomes.
- One- and 5-year graft survival rates were 86% and 69%, respectively, significantly higher in patients without DGF.
Conclusions:
- Cold storage duration and DGF significantly impact graft survival in dual-kidney transplantation.
- Prompt graft function is associated with better long-term outcomes.
- Dual-kidney transplantation demonstrates excellent 5-year graft survival rates.