Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bcl11a is essential for normal lymphoid development.

Pentao Liu1, Jonathan R Keller, Mariaestela Ortiz

  • 1Mouse Cancer Genetics Program, National Cancer Institute-Frederick, Maryland 21702, USA.

Nature Immunology
|April 30, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of endothelial Dlc1 in embryonic vascular development and adult bone marrow hematopoiesis.

Leukemia·2026
Same author

BRAF V600E Expression in c-Kit+ Interstitial Cells of Cajal Drives Gastrointestinal Stromal Tumor Formation in Mice.

Cancer research communications·2026
Same author

A single BRCA2 BRC repeat supports viability while multiple repeats ensure resilience under stress.

bioRxiv : the preprint server for biology·2026
Same author

Abcb5-deficient mice show a subtle, pleiotropic phenotype indicating a role for this transporter in intermediary metabolism.

iScience·2025
Same author

Phosphorylation of SNAP-25 at Ser187 is enhanced following its cleavage by Botulinum Neurotoxin Serotype A, promoting the dominant-negative effect of the resulting fragment.

PLoS pathogens·2025
Same author

ANTXR1 blockade enhances cardiac function in preclinical models of heart failure.

Nature cardiovascular research·2025
Same journal

Author Correction: An atlas of genetic effects on cellular composition of the tumor microenvironment.

Nature immunology·2026
Same journal

Exhausted CD8<sup>+</sup> T cell fate is programmed by dynamic CTCF-mediated enhancer activation and invariant CTCF-imposed barriers.

Nature immunology·2026
Same journal

Mapping self-associating chromatin hubs identifies Id proteins as key determinants of exhausted CD8<sup>+</sup> T cell fate.

Nature immunology·2026
Same journal

Exhausted CD8<sup>+</sup> T cell subsets differ a TAD.

Nature immunology·2026
Same journal

Pregnancy-induced tissue-resident memory-like T cells contribute to tumor control in breast cancer.

Nature immunology·2026
Same journal

Mechanosensing by T cells promotes a tissue-resident memory transcriptional program.

Nature immunology·2026
See all related articles

Bcl11a is crucial for developing B cells and T cells. Bcl11a deficiency in precursor cells leads to B cell absence and T cell leukemia, suggesting a tumor suppressor role.

Area of Science:

  • Immunology
  • Developmental Biology
  • Oncology

Background:

  • Bcl11a (Evi9) acts as a proto-oncogene in myeloid and B cells.
  • Its role in postnatal development and lymphopoiesis is not fully understood.

Purpose of the Study:

  • To investigate the essential functions of Bcl11a in postnatal development and lymphopoiesis.
  • To elucidate the molecular mechanisms underlying Bcl11a's role in B and T cell development.

Main Methods:

  • Generation and analysis of Bcl11a mutant mice.
  • Phenotypic and gene expression studies.
  • Fetal liver precursor cell transplantation assays.

Main Results:

  • Bcl11a mutant embryos exhibit a complete absence of B cells and altered T cell populations.

Related Experiment Videos

  • Bcl11a functions upstream of Ebf1 and Pax5 in the B cell differentiation pathway.
  • Transplantation of Bcl11a-deficient cells into wild-type hosts resulted in host-derived T cell leukemia.

    • Conclusions:

    • Bcl11a is essential for normal B cell development and lymphopoiesis.
    • Bcl11a acts as a non-autonomous tumor suppressor gene, inhibiting T cell leukemia development.