William Harvey's epitaph

Constrained by limited energy and resources, organisms must compromise between offspring quantity and parental investment. This trade-off is represented by two primary reproductive strategies; K-strategists produce few offspring but provide substantial parental support, whereas r-strategists produce much progeny that receives little care. These strategies are related to an organism’s survival likelihood across its lifespan, which is represented by a survivorship curve. Three general types of...

Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and pro-apoptotic...

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...

Experience suggests that an object at rest remains at rest if left alone, and that an object in motion tends to slow down and stop unless some effort is made to keep it moving. However, Newton's first law gives a deeper explanation of this observation. The study of Newton's laws is like recognizing patterns in nature from which further patterns can be discovered. The genius of Galileo, who first developed the idea for the first law of motion, and Newton, who clarified it, was to ask the...

Our everyday observation tells us that all objects close to the Earth naturally tend to fall to the ground. Early philosophers assumed that this downward force was unique to Earth. By the 16th century, Nicolaus Copernicus (1473-1543) put forward the heliocentric theory, which suggested that Earth and other planets orbited the sun, while the Moon orbited the Earth. However, it was Isaac Newton (1642-1727) who linked these two motions together in the 17th century. He reasoned that the force of...

Sir Isaac Newton established the universality of the law of gravitational attraction based on empirical evidence and inductive reasoning. He published his work in Philosophiae Naturalis Principia Mathematica ("the Principia") on July 5, 1687.
Newton's law of gravitational attraction is a fundamental law of physics that governs the attraction between objects. It states that the magnitude of the gravitational force between any two objects is proportional to their masses and inversely proportional...