Effect of alvitili on immunological parameters in often ailing children
Natalia Yu Sotnikova1, Olga A Gromova, Anna V Kudryashova
1V.N. Gorodkov State Scientific-Research Institute of Maternity and Childhood, Ivanovo, Russia.
Insights
Alvitili, a vitamin preparation, effectively rehabilitates frequently ill children by improving key immune system markers. This study shows it normalizes immune cell levels and boosts antibody production in children with vitamin deficiencies.
Area of Science:
- Pediatrics
- Immunology
- Nutritional Science
Background:
- Frequent respiratory illnesses in children are linked to impaired immune reactivity.
- The rehabilitation of frequently ill children requires further elucidation.
- Vitamin deficiency is common in children experiencing recurrent illnesses.
Purpose of the Study:
- To evaluate the impact of Alvitili on immunological parameters in frequently ill children.
- To assess Alvitili's efficacy in rehabilitating children with recurrent respiratory diseases.
- To determine if Alvitili can correct vitamin deficiencies affecting immune function.
Main Methods:
- A study involving 30 children aged 3-8, divided into a frequently ill group and a healthy control group.
- Administration of Alvitili (5 ml thrice daily for 3 weeks) to the frequently ill group.
- Standard immunological examinations before and after Alvitili treatment, including T lymphocyte subsets, activation markers, HLA-DR, MIF, IgM, IgG, and neutrophil FcgammaRIII expression.
Main Results:
- Alvitili normalized decreased T lymphocyte and T helper cell levels.
- Enhanced expression of early activation markers on T lymphocytes and T helpers was observed.
- The preparation normalized HLA-DR(+) T cells, MIF production, IgM synthesis, and IgG levels, while also stimulating FcgammaRIII expression on neutrophils.
Conclusions:
- Alvitili demonstrates effectiveness in the rehabilitation of frequently ill children.
- The vitamin preparation compensates for common vitamin deficiencies in these children.
- Alvitili normalizes multiple immunological parameters, supporting immune system recovery.
Abstract:
The problem of the rehabilitation of often ailing children is not yet elucidated despite of a substantial amount of research done in this field. It is acknowledged that the impairment of immune reactivity is a pathogenetic foundation of often and prolonged respiratory diseases in children. In this connection, the aim of the study was to evaluate the effect of alvitili on the main immunologic parameters in children who get ill frequently. Alvitili, produced by Solvay Pharma (France), is one of the promising vitamin preparations that contain all necessary water-soluble and oil-soluble vitamins. Thirty children 3-8 years of age were selected for the study: 15 children were included in the group of often ailing children and 15 healthy children made the control group. Immunological examination was carried out using standard methods before and after administration of alvitili at a dose of 5 ml 3 times a day for 3 weeks. Alvitili normalized originally decreased levels of T lymphocytes and T helpers, enhanced expression of early activation markers on the surface of T lymphocytes and T helpers, normalized the number of HLA DR(+) T cells and the level of MIF production. The drug stimulated IgM synthesis, expression of FcgammaRIII on the surface of neutrophils and normalized the IgG level. The study showed that alvitili is an effective remedy in the rehabilitation of ill children, since it compensates a vitamin deficiency that is frequently seen in often-ailing children, and it normalizes various immunological parameters.
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