Managing thrombolysis in the accident and emergency department

The optimal management of acute myocardial infarction (AMI) today is founded upon the 'open artery' theory and driven by the need for early reperfusion strategies. Numerous randomised controlled trials demonstrate the unequivocal benefit of thrombolytic therapy in reducing mortality and improving long-term prognosis. These benefits are most striking when the thrombolytic therapy is given early. The National Service Framework for Coronary Heart Disease introduced national standards to reduce both 'call to needle' and 'door to needle' times to further augment early treatment. Subsequently many hospitals established 'fast track', 'nurse-led' or 'nurse initiated' thrombolysis within both the Accident and Emergency and Coronary Care Departments. This paper reviews these strategies and considers the benefits and limitations associated with the role of the 'thrombolysis nurse'. Thrombolysis nurses work to agreed protocols and play a fundamental role in the assessment and appropriate management of patients with acute MI. The evidence suggests that thrombolysis nurses are safe and effective in their practice and make a significant contribution to patient outcomes and enhance interprofessional education and practice.