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Drug combinations for mania.

Francis M Mondimore1, Gregory A Fuller, J Raymond DePaulo

  • 1Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA.

The Journal of Clinical Psychiatry
|May 2, 2003
PubMed
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New bipolar disorder treatments require careful decisions due to limited data. Clinicians often use combination therapy, especially for mania, but evidence comparing specific regimens is scarce.

Area of Science:

  • Psychiatry
  • Pharmacology
  • Clinical Medicine

Background:

  • The increasing availability of novel medications for bipolar disorder presents challenges for clinicians managing complex cases.
  • Insufficient research data complicates treatment decisions for difficult-to-control bipolar disorder, leading to increased use of combination or adjunctive therapies.

Purpose of the Study:

  • To review clinical data on individual agents for potential combination treatment in bipolar disorder.
  • To provide guidance for clinicians on selecting initial agents for combination therapy, particularly for mania.

Main Methods:

  • Review of existing clinical data on individual agents used in combination therapy for bipolar disorder.
  • Emphasis on evidence related to the treatment of mania.

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Main Results:

  • Many studies support the effectiveness of add-on agents for mania unresponsive to monotherapy.
  • Limited controlled trials directly compare specific combination regimens.

Conclusions:

  • Combination therapy is increasingly necessary for bipolar disorder management, especially for mania.
  • Clinicians should consider agents with established efficacy when initiating combination treatment for bipolar disorder.