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Related Experiment Videos

Inflammatory bowel disease: management issues during pregnancy.

Simone Ferrero1, Nicola Ragni

  • 1Dipartimento di Ostetricia e Ginecologia, Università degli Studi di Genova, Padiglione 1, Ospedale San Martino, Largo R. Benzi 1, 16132, Genova, Italy. simoneferrero@libero.it

Archives of Gynecology and Obstetrics
|May 2, 2003
PubMed
Summary

Most medications for inflammatory bowel disease (IBD) are safe during pregnancy, except methotrexate. Controlling IBD before and during pregnancy is crucial for maternal and fetal health.

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Area of Science:

  • Reproductive medicine
  • Gastroenterology
  • Obstetrics

Background:

  • Inflammatory bowel disease (IBD) frequently impacts women of reproductive age.
  • Managing IBD during pregnancy presents challenges for obstetricians.

Purpose of the Study:

  • To review the safety of IBD medications during pregnancy.
  • To provide guidance on managing IBD in pregnant women.

Main Methods:

  • Literature review of IBD medications and their effects on pregnancy.
  • Analysis of safety data for various IBD treatments.

Main Results:

  • Sulfasalazine, 5-aminosalicylic acid, azathioprine, and mercaptopurine are generally considered safe.
  • Methotrexate is contraindicated due to abortifacient effects and teratogenicity.

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  • Cyclosporine may be associated with fetal growth issues.
  • Limited data exists for Infliximab, metronidazole, and ciprofloxacin in long-term use.

    • Conclusions:

    • Disease control before and during pregnancy is vital for optimal outcomes.
    • A multidisciplinary approach involving obstetricians and gastroenterologists is essential.
    • Patient education regarding pregnancy and IBD is a key component of care.