Related Experiment Video

Updated: Sep 26, 2026

A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice
06:27

A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice

Published on: July 20, 2022

Is dialysis modality a factor in survival of patients with ESRD and HIV-associated nephropathy?

Tejinder S Ahuja1, Neil Collinge, James Grady

  • 1Department of Medicine, Division of Nephrology, University of Texas Medical Branch, Galveston, TX, USA. tahuja@utmb.edu

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|May 2, 2003
PubMed

Insights

Dialysis modality does not impact survival for patients with HIV-associated nephropathy (HIVAN) and end-stage renal disease (ESRD). Patients with HIVAN and ESRD can choose between hemodialysis (HD) or peritoneal dialysis (PD) as modality is not a survival predictor.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Public Health

Background:

  • HIV-associated nephropathy (HIVAN) is a leading cause of end-stage renal disease (ESRD) in young African Americans.
  • Hemodialysis (HD) theoretically may increase HIV replication via cytokine release.
  • The impact of dialysis modality on HIVAN patient survival is unknown.

Purpose of the Study:

  • To determine if dialysis modality affects survival in patients with HIVAN and ESRD.

Main Methods:

  • Analysis of the US Renal Data System database (1995-1999).
  • Inclusion of 6,053 patients with ESRD and HIVAN initiating dialysis.
  • Cox-proportional hazard analysis adjusting for demographic variables and initiation year.

Main Results:

  • 89% of patients were black; 88% received HD, 12% received peritoneal dialysis (PD).
  • No significant difference in survival between HD and PD (HR, 1.01; 95% CI, 0.91-1.13).
  • Survival remained similar between modalities when censoring for modality switch.

Conclusions:

  • Dialysis modality is not a predictor of survival for patients with HIVAN and ESRD.
  • Patients with HIVAN and ESRD should be offered a choice of dialysis modality.
Abstract

Related Concept Videos

Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
Dialysis01:27

Dialysis

Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...