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[Microvessel density index as a prognostic factor in a low histological differentiation stage of endometrial
Wiesław Szymański1, Jacek Fórmaniak, Marek Szymański
1Katedry i Kliniki Połoznictwa i Chorób Kobiecych AM w Bydgoszczy.
Objective:
Angiogenesis in malignant tumors is a prognostic factor associated with tumor growth and metastasis. Studies of angiogenesis in breast, prostate and lung cancer showed that neovascularisation correlates with likelihood of metastasis and recurrence. Our study was to evaluate microvessel density as a prognostic factor in endometrial cancer.
Methods:
Between 1995-1999, 58 women were treated for endometrial carcinoma. The primary treatment consisted of total abdominal hysterectomy, bilateral salpingoophorectomy and pelvic lymphadenectomy. The microscopic examination of paraffin blocks showed the areas of the deepest myometrial invasion. The microvessels within the invasive cancer were highlighted by means of immuno-cytochemical staining to detect CD-31 antigen.
Results:
Microvessel count was related to likelihood of recurrence. We found statistically significant differences between patients who died after operation and patients with nonrecurrence process. All patients were in the same stage and grade of endometrial carcinoma.
Conclusion:
Microvessel density index seems to be an important factor for planing postoperation treatment in endometrial carcinoma.