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[St. Mary's Thistle: an overview].

G Laekeman1, S De Coster, K De Meyer

  • 1K.U.Leuven.

Journal De Pharmacie De Belgique
|May 2, 2003
PubMed
Summary
This summary is machine-generated.

St. Marys Thistle, containing silymarine, is a registered medicine in Belgium. Silymarine demonstrates antioxidant properties and improves liver health outcomes in various toxic conditions and liver diseases.

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Area of Science:

  • Pharmacology
  • Hepatology
  • Phytochemistry

Background:

  • St. Marys Thistle (Silybum marianum) is a plant from the Compositae family.
  • Its seeds yield silymarine, a complex of flavonolignanes with antioxidant properties.
  • Silymarine is the active compound in Legalon, a prescription-only medicine registered in Belgium.

Purpose of the Study:

  • To evaluate the hepatotropic properties of St. Marys Thistle extract (silymarine).
  • To assess the efficacy of silymarine in mitigating liver damage from various toxins.
  • To determine the clinical benefit of silymarine in patients with liver diseases.

Main Methods:

  • Review of existing data on silymarine's effects.
  • Analysis of animal studies involving induced liver toxicity (mushroom toxins, medicines, heavy metals, solvents).

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  • Observation of clinical outcomes in patients with alcohol-related liver damage and viral hepatitis.

    • Main Results:

    • Silymarine exhibits both preventive and curative effects against liver toxins in animal models.
    • Silymarine accumulates in the liver, targeting therapeutic action.
    • It improves prognosis in cases of toxic mushroom ingestion and reduces mortality in alcohol-induced liver damage.
    • Potential benefits for hepatitis B and C require further investigation.

    Conclusions:

    • Silymarine, derived from St. Marys Thistle, is a valuable therapeutic agent for liver conditions.
    • Its safety profile is comparable to placebo, suggesting a favorable risk-benefit ratio.
    • Further research is warranted to fully elucidate its role in viral hepatitis management.