[Is atropine efficient in para-bulbar injections?]

Area of Science:

• Ophthalmology
• Neuroscience
• Pharmacology

Background:

• Atropine is known to possess antispastic effects on blood vessels.
• Neuro-retinal diseases can be associated with compromised ocular blood flow.

Purpose of the Study:

• To investigate the impact of atropine on ocular arterial blood flow in patients with neuro-retinal diseases.
• To quantify changes in blood flow velocity in the ophthalmic, central retinal, and ciliary arteries following atropine administration.

Main Methods:

• A prospective study involving 17 eyes of patients diagnosed with neuro-retinal diseases.
• Parabulbar administration of 1 ml Atropine 1:1000.
• Ocular arterial blood flow was measured using Doppler ultrasound at baseline, 15 minutes, and 30 minutes post-injection.
• Statistical analysis was performed using the t-Student method.

Main Results:

• Atropine administration led to observable variations in blood flow within the studied ocular arteries.
• The most significant increase in blood flow velocity within the central retinal artery was noted 30 minutes after atropine administration.
• The antispastic effect of atropine on ocular vasculature appeared dose- and time-dependent.

Conclusions:

• Atropine demonstrates a positive effect on enhancing ocular blood flow, particularly in the central retinal artery, in patients with neuro-retinal conditions.
• The findings suggest that atropine may be a viable therapeutic agent for improving retinal perfusion in specific ophthalmic diseases.
• Further research is warranted to explore the long-term efficacy and safety of atropine for managing ocular vascular disorders.