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Related Experiment Videos

Plasma D-dimer concentrations in different clinical conditions.

K Ver Elst1, K Jochmans, A De Pauw

  • 1Laboratorium Hematologie en Hemostase, Academisch Ziekenhuis Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussel, België.

Acta Clinica Belgica
|May 2, 2003
PubMed
Summary

D-dimer (DD) testing is frequently positive in various conditions beyond blood clots. Elevated DD levels occur in many diseases and physiological states, not just deep venous thrombosis or pulmonary embolism.

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Area of Science:

  • Biochemistry
  • Hematology
  • Clinical Pathology

Background:

  • D-dimers (DD) are markers of fibrinolysis and coagulation activation.
  • Low DD levels effectively rule out deep venous thrombosis (DVT) and pulmonary embolism (PE).
  • Positive DD results are observed in numerous diseases and physiological conditions, including advanced age and pregnancy.

Purpose of the Study:

  • To demonstrate the prevalence of positive D-dimer (DD) results in diverse medical conditions and physiological states.
  • To investigate variations in DD positivity across different pathological conditions.
  • To assess the clinical utility and physician request patterns for DD testing.

Main Methods:

  • Retrospective analysis of medical records for 574 consecutive patients (outpatients and inpatients).

Related Experiment Videos

  • Examination of plasma D-dimer (DD) concentrations and associated clinical diagnoses.
  • Evaluation of clinician request attitudes and understanding of DD test relevance.

    • Main Results:

    • Overall D-dimer (DD) positivity rate was 64%, with a median concentration of 775 µg/L.
    • Elevated DD concentrations were observed across a wide spectrum of clinical conditions.
    • Clinician requests for DD testing were often frequent and not always clinically relevant, indicating potential misunderstanding of results.

    Conclusions:

    • Positive D-dimer (DD) results are common in various diseases and physiological conditions, extending beyond thromboembolic events.
    • The clinical interpretation and relevance of positive DD results require careful consideration within the patient's overall clinical context.
    • Optimizing the appropriate use of DD testing is crucial to avoid unnecessary confusion and ensure clinical relevance.