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Updated: Sep 26, 2026

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
Published on: February 3, 2012
[Type I autoimmune hepatitis. An atypical case]
Pierluigi Blanc1, Donatella Macchia, Augusto Giannini
1Unità Operativa Malattie Infettive, Ospedale S. Maria Annunziata, Firenze. pierblanc@virgilio.it
Abstract:
Typically, autoimmune hepatitis (AIH) arises in young women, but recent papers have shown that it can affect older people too. The authors describe a case of AIH in a 70 ys old man affected by acute cholostatic hepatitis. The diagnosis of type I AIH was based on immunological features (high levels of ANA) together with histological picture in the absence of other known causes of hepatitis. Corticosteroid therapy is an effective treatment of type I AIH in older patients. AIH should be considered for the diagnosis of hepatitis in older male patients too.
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