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Prevalence of anticardiolipin antibodies in various thrombotic conditions: a hospital-based study

S Chandrashekhara1, R Kirthi, Joyce Varghese

  • 1Department of Immunology, MS Ramaiah Medical College, Bangalore.

The Journal of the Association of Physicians of India
|May 2, 2003
PubMed

Insights

Anticardiolipin antibodies (aCL) are a common acquired thrombophilic defect. This study found aCL IgG in 20.77% of patients, with deep vein thrombosis being the most frequent manifestation.

Area of Science:

  • Hematology
  • Immunology
  • Vascular Medicine

Background:

  • Thrombosis is a leading global cause of mortality.
  • Anticardiolipin antibodies (aCL) are recognized as a frequent acquired protein defect contributing to thrombosis.
  • Understanding the incidence of aCL in diverse thrombotic conditions is crucial.

Purpose of the Study:

  • To determine the incidence of anticardiolipin antibodies (aCL) in patients presenting with various thrombotic events.
  • To investigate the association between aCL IgG and specific thrombotic conditions.

Main Methods:

  • Retrospective screening of 302 patients for aCL IgG using enzyme-linked immunosorbent assay (ELISA).
  • Collection of detailed clinical and epidemiological data from patient records and examinations.

Main Results:

  • High titers of aCL IgG were detected in 65 (20.77%) of the 302 patients.
  • Deep vein thrombosis (DVT) was the most common thrombotic event (29.8%), with aCL IgG incidence of 13.79%.
  • aCL IgG was also observed in coronary artery (25.0%), central nervous system arteries (17.21%), and peripheral arteries (18.75%) thrombosis.

Conclusions:

  • Anticardiolipin antibodies (aCL) represent the most prevalent acquired thrombophilic defect.
  • Further epidemiological data specific to the population studied is necessary to refine strategies for thrombosis research in aCL-positive individuals.
Abstract

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