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Published on: November 30, 2022

A general overview of the use of ibuprofen in paediatrics

Elisabeth Autret-Leca1

  • 1Tours University Hospital, France.

International Journal of Clinical Practice. Supplement
|May 2, 2003
PubMed

Insights

Ibuprofen effectively treats pain and fever in children, with a linear dose-response relationship. It is well-tolerated and safer in overdose compared to other common medications.

Area of Science:

  • Pediatric Pharmacology
  • Pain Management
  • Rheumatology

Background:

  • Ibuprofen is a common non-steroidal anti-inflammatory drug (NSAID) used for acute pain, fever, and juvenile idiopathic arthritis in children.
  • Understanding its pediatric pharmacokinetics is crucial for safe and effective dosing.

Purpose of the Study:

  • To review the efficacy and safety of ibuprofen in pediatric patients.
  • To establish the optimal dosing range and compare its effects to other antipyretics and analgesics.

Main Methods:

  • Review of clinical trials and pharmacokinetic data for ibuprofen in children.
  • Comparison of ibuprofen's efficacy and safety against paracetamol and aspirin.

Main Results:

  • Ibuprofen exhibits linear pharmacokinetics in children, similar to adults, with an effective dose range of 7.5-10 mg/kg.
  • It demonstrates comparable or superior efficacy to paracetamol and is as effective as aspirin, with a longer duration of action.
  • Adverse effects are typical of NSAIDs, but ibuprofen appears better tolerated in children and safer in overdose.

Conclusions:

  • Ibuprofen is an effective and well-tolerated analgesic and antipyretic for pediatric use.
  • Its safety profile, particularly in overdose, makes it a favorable option compared to paracetamol and aspirin.

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