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Related Experiment Videos

Ibuprofen overdose.

Glyn Volans1, Jane Monaghan, Mark Colbridge

  • 1Medical Toxicology Unit, Guy's and St Thomas' Hospital, London, UK.

International Journal of Clinical Practice. Supplement
|May 2, 2003
PubMed
Summary
This summary is machine-generated.

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Ibuprofen overdose is common, but serious toxic effects are rare. Most patients experience mild or no symptoms, and management is straightforward.

Area of Science:

  • Toxicology
  • Pharmacology

Background:

  • Ibuprofen overdose inquiries constitute a significant portion of poison control center workload.
  • Unlike other NSAIDs, ibuprofen overdose typically lacks unique pathophysiological findings beyond known pharmacological effects.

Purpose of the Study:

  • To review the clinical presentation and management of ibuprofen overdose.
  • To assess the toxicity profile of ibuprofen overdose, including factors like formulation and co-ingestions.

Main Methods:

  • Analysis of case reports and enquiry data concerning ibuprofen overdose.
  • Review of documented toxic effects related to ibuprofen and its metabolites.

Main Results:

  • The majority of ibuprofen overdose cases (over 85%) present with asymptomatic or mild symptoms.

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  • Fatal outcomes are rare and often associated with complicating factors like poly-drug ingestion or pre-existing conditions.
  • Modified-release formulations and co-ingestion with ethanol do not appear to increase toxicity risk.

    • Conclusions:

    • Ibuprofen overdose is generally associated with a favorable prognosis and straightforward management.
    • Serious toxicity from ibuprofen overdose is uncommon, even with significant ingestions.