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Personalised prescribing for asthma--is pharmacogenetics the answer?
1Division of Respiratory Medicine, Clinical Sciences Building, City Hospital, Hucknall Road, Nottingham, NG5 1PB, UK.
The Journal of Pharmacy and Pharmacology
|May 2, 2003
Summary
Genetic factors significantly influence asthma medication response, accounting for 60-80% of treatment variability. Identifying these genetic variants can personalize asthma therapies and improve drug development.
Area of Science:
- Pharmacogenetics
- Asthma Therapeutics
- Genetics
Background:
- Individual responses to asthma medications are complex, influenced by social, environmental, and genetic factors.
- Genetic factors are estimated to contribute 60-80% to the variability in asthma treatment responsiveness.
Purpose of the Study:
- To review current methods for identifying genes and genetic variants related to asthma treatment response.
- To detail the pharmacogenetics of major asthma medication classes.
- To discuss the future impact of pharmacogenetics on the pharmaceutical industry and clinical practice.
Main Methods:
- Review of current literature on gene identification methods.
- Detailed examination of pharmacogenetic studies for main asthma treatment groups.
- Discussion of industry and clinical implications.
Main Results:
- Genetic factors play a substantial role in asthma treatment heterogeneity.
- Identification of specific genetic variants can inform personalized medicine approaches.
- Pharmacogenetics offers potential for improved drug efficacy prediction and development.
Conclusions:
- Understanding the genetic basis of asthma medication response is crucial for advancing treatment strategies.
- Pharmacogenetics holds significant promise for optimizing asthma care and pharmaceutical innovation.
- Future clinical practice and drug development will be increasingly shaped by pharmacogenetic insights.