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[GDNF expression following the severe brain injury in rats]
Xin Wang1, Zhi-gang Liao, Min Liu
1Forensic Pathology Department, School of Legal Medicine, Sichuan University, Chengdu 610041. xinwang974@sohu.com
Fa Yi Xue Za Zhi
|May 3, 2003
Abstract
Objective:
To evaluate the changes of GDNF after severe brain injury.
Methods:
Changes GDNF in cortex, thalamus and pontine was observed by using immunohistochemistry and image analysis technique.
Results:
The lever of GDNF was increasing at 1 d, reaching peak at 3 d, not obviously decreasing at 5 d and still higher than normal at 7 d after severe brain injury.
Conclusion:
As an objective indication, the time sequence regularity of GDNF after brain injury may be applied in brain injury time estimation.