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[A study on the expression of C-FOS protein after experimental rat brain concussion]
Feng Wang1, Yong-hong Li, Yong-liang Hu
1Department of Forensic Medicine, Wannan Medical College, Wuhu 241001. wangfeng760914@Sohu.com
Objective:
To study the relationship between expression of C-FOS protein and brain concussion and find a sensitive marker of diagnosis of the brain concussion.
Methods:
Fifty-five rats were randomly divided into brain concussion groups and control group. The expression of C-FOS protein was microscopically observed by immunohistochemical method.
Results:
There were negative expression of C-FOS protein in control group. In brain concussion group, however, positive expression of C-FOS protein in some neurons was seen at 15 min after brain concussion, and reach to the peak at 6 h after brain concussion, then decreased gradually.
Conclusion:
These findings suggest that detection of C-FOS protein could be an index of diagnosis of brain concussion and a sensitive marker of timing of injury after brain concussion.