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Updated: Aug 7, 2026
10:24
Ischemic Tissue Injury in the Dorsal Skinfold Chamber of the Mouse: A Skin Flap Model to Investigate Acute Persistent Ischemia
Published on: November 17, 2014
[Morphological changes of tissues after extensive soft tissue injury]
Ge Li1, Jun-bao Lu, Qing-song Yao
1Department of Forensic Pathology, Sun Yat-Sen University, Guangzhou 510089.
Fa Yi Xue Za Zhi
|May 3, 2003
Summary
This study establishes an animal model for extensive soft tissue injury, providing crucial pathological data. This research aids in diagnosing the cause of death in crush syndrome cases.
Area of Science:
- Pathology
- Toxicology
- Forensic Medicine
Context:
- Extensive soft tissue injury and crush syndrome pose diagnostic challenges.
- Understanding pathological changes is vital for determining the cause of death.
- Current diagnostic methods require further refinement.
Purpose:
- To establish an animal model of extensive soft tissue injury.
- To investigate pathological morphological changes using Hematoxylin and Eosin (HE) and Immunohistochemistry (IHC) staining.
- To accumulate data for diagnosing the cause of death in crush syndrome.
Summary:
- An animal model for extensive soft tissue injury was successfully established.
- Myoglobin (Mb) positive rates were observed at 60%, 75%, and 95%.
- Heat Shock Protein 70 (HSP70) showed a 90% positive rate in both heart and brain tissues.
Impact:
- Provides a foundational animal model for future research on crush syndrome.
- Contributes valuable pathological data to the field of forensic medicine.
- Enhances diagnostic capabilities for determining the cause of death in severe trauma cases.
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