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Published on: February 10, 2023
Analysis of the mitochondrial genome in sudden infant death syndrome
A M Divne1, P Råsten-Almqvist, J Rajs
1Department of Genetics and Pathology, Uppsala University, Sweden.
Aim:
To investigate the mitochondrial genome and its association with sudden infant death syndrome (SIDS).
Methods:
Twenty SIDS infants were screened for previously reported mitochondrial DNA mutations using direct sequencing. The whole mitochondrial genome was also sequenced for six of the infants.
Results:
Three substitutions, A11467G, A12308G and G12372A, comprising a haplogroup were present in four infants diagnosed as pure SIDS. This haplogroup was also common in a control group.
Conclusions:
No specific mutation or polymorphism was found in association with SIDS.
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