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Enalapril-induced acute recurrent pancreatitis
A Carnovale1, P Esposito, P Bassano
1Internal Medicine Department, 3rd Division, Cardarelli Hospital, 80131 Napoli, Italy.
Summary
Enalapril, an angiotensin-converting enzyme inhibitor, can rarely cause acute pancreatitis. A patient case confirms this link, highlighting the need for vigilance with this common medication.
Area of Science:
- Pharmacology
- Gastroenterology
- Drug-induced diseases
Background:
- Enalapril is a widely prescribed angiotensin-converting enzyme (ACE) inhibitor.
- ACE inhibitors are associated with various adverse effects.
- Acute pancreatitis is a rare but serious adverse event linked to ACE inhibitors.
Observation:
- A case report details a patient experiencing acute pancreatitis.
- The patient was taking enalapril as prescribed.
- Recurrence of pancreatitis upon inadvertent rechallenge with enalapril was observed.
Findings:
- The clinical presentation and rechallenge strongly suggest enalapril as the causative agent.
- The pancreatitis was severe and necrotizing in nature.
- This case adds to the limited evidence of enalapril-induced pancreatitis.
Implications:
- Clinicians should consider enalapril as a potential cause of acute pancreatitis in patients presenting with this condition.
- Discontinuation of enalapril may be necessary for patients with suspected drug-induced pancreatitis.
- Further research may be warranted to elucidate the mechanism of enalapril-induced pancreatitis.