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The delta2 glutamate receptor: 10 years later.

Michisuke Yuzaki¹

¹Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 332 N. Lauderdale Street, Memphis, TN 38105-2794, USA. michi.yuzaki@stjude.org

Neuroscience Research

|May 3, 2003

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The orphan glutamate receptor delta2 (GluRdelta2) is essential for cerebellar function, as its absence causes ataxia. Its precise role remains unclear, but it

Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

The orphan glutamate receptor delta2 (GluRdelta2) is primarily found in Purkinje cells, vital for cerebellar functions.
Mice lacking the GluRdelta2 gene exhibit ataxia and impaired synaptic plasticity, indicating its critical role.
The exact molecular mechanisms of GluRdelta2's function in the cerebellum have been largely unknown.

Purpose of the Study:

To elucidate the structure and function of the GluRdelta2 receptor.
To investigate the mechanisms underlying GluRdelta2's role in cerebellar function using mutant mouse models.
To propose hypotheses regarding GluRdelta2's function based on experimental findings.

Main Methods:

Analysis of mutant mouse models, including lurcher, hotfoot, and GluRdelta2 knockout mice.

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Examination of GluRdelta2's channel pore structure and functionality.

Investigation of GluRdelta2's cell surface transport and its correlation with cerebellar phenotypes.

Main Results:

GluRdelta2 possesses a channel pore similar to other glutamate receptors, which can be functional, particularly in the presence of the lurcher mutation.
Proper transport of GluRdelta2 to the Purkinje cell surface is necessary for its function; its absence leads to ataxia in hotfoot mice.
GluRdelta2-null mice show potential alterations in Purkinje cell innervation by climbing fibers, possibly due to uninnervated parallel fiber spines.

Conclusions:

GluRdelta2's function is dependent on its presence at the Purkinje cell surface.
Mutant mouse studies provide significant insights into GluRdelta2's structure-function relationship and its role in cerebellar circuitry.
Further research on GluRdelta2 is crucial for understanding both normal and abnormal cerebellar function and neurological disorders.