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Long-term survival in patients hospitalized with congestive heart failure: relation to preserved and reduced left

Finn Gustafsson1, Christian Torp-Pedersen, Bente Brendorp

  • 1Department of Cardiology and Endocrinology E, Frederiksberg University Hospital, Frederiksberg, Denmark.

European Heart Journal
|May 3, 2003
PubMed

Insights

Left ventricular systolic function significantly impacts survival in hospitalized heart failure patients. Better systolic function, especially in younger patients with ischemic heart disease, is linked to lower mortality risk.

Area of Science:

  • Cardiology
  • Heart Failure Research
  • Clinical Outcomes

Background:

  • Congestive heart failure (CHF) is a major cause of morbidity and mortality.
  • Left ventricular systolic function is a key determinant of cardiac performance.
  • Prognostic factors in CHF, including co-morbidities, require ongoing investigation.

Purpose of the Study:

  • To assess the impact of left ventricular systolic function on survival in a large cohort of hospitalized heart failure patients.
  • To investigate the interplay between left ventricular systolic function and co-morbid conditions on prognosis.

Main Methods:

  • Analysis of survival data from 5491 hospitalized heart failure patients (1993-1996).
  • Standardized echocardiograms used to estimate left ventricular systolic function via wall motion index score (available for 95% of patients).
  • Long-term follow-up (5-8 years) to determine mortality rates.

Main Results:

  • A low wall motion index (indicating impaired systolic function) was a strong independent predictor of death (RR 0.60).
  • The prognostic significance of systolic function was greater in younger patients and those with a history of myocardial ischemia.
  • Mortality remained high even in patients with preserved systolic function (1-year mortality 19%).

Conclusions:

  • Left ventricular systolic function is a critical prognostic factor in hospitalized heart failure.
  • Mortality risk is inversely related to systolic function, particularly in younger patients with ischemic heart disease.
  • Even patients with preserved systolic function face substantial mortality risk, highlighting the severity of heart failure.
Abstract

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