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Updated: Sep 10, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
Intrinsic T cell defects in systemic autoimmunity
Philip L Kong1, Jared M Odegard, Farida Bouzahzah
1Section of Rheumatology, Department of Internal Medicine, and Section of Immunobiology, Yale School of Medicine, New Haven, Connecticut 06520, USA.
Abstract:
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of T cell tolerance to nuclear antigens. Studies in mice and humans have demonstrated that T cells from individuals with lupus are abnormal. Here, we review the known T cell defects in lupus and their possible biochemical nature, genetic causes, and significance for lupus pathogenesis.
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