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The effect of zinc supplementation on linear growth, body composition, and growth factors in preterm infants

N Marta Díaz-Gómez1, Eduardo Doménech, Flora Barroso

  • 1Research Unit, University Hospital of the Canaries, La Laguna, Spain. nmdiaz@ull.es

Pediatrics
|May 3, 2003
PubMed

Insights

Zinc supplementation improved linear growth in premature infants. This study found that supplementing formula with zinc led to greater increases in length and total body water.

Area of Science:

  • Neonatal nutrition
  • Pediatric growth and development
  • Mineral metabolism

Background:

  • Premature infants often experience growth challenges.
  • Nutritional deficiencies, including zinc, can impair growth in this population.
  • Optimizing nutrient intake is crucial for catch-up growth and long-term health outcomes.

Purpose of the Study:

  • To investigate the impact of zinc supplementation on linear growth.
  • To assess effects on body composition and key growth factors in preterm infants.
  • To determine optimal zinc and copper levels in formula for premature infants.

Main Methods:

  • A double-blind, randomized clinical trial involving 36 preterm infants.
  • Infants received standard formula with or without supplemental zinc and copper.
  • Measurements included anthropometry, bioelectrical impedance, and serum/erythrocyte mineral and growth factor levels.

Main Results:

  • The zinc-supplemented group showed significantly greater linear growth.
  • Increased total body water and serum skeletal alkaline phosphatase (sALP) levels were observed in the supplemented group.
  • Higher serum and erythrocyte zinc levels and lower serum copper levels were noted in the supplemented group.

Conclusions:

  • Zinc supplementation positively influences linear growth in premature infants.
  • Adequate zinc intake is essential for promoting healthy growth and development in this vulnerable population.
  • Further research could explore long-term growth trajectories and optimal supplementation strategies.
Abstract

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