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Related Experiment Video

Updated: May 4, 2026

Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes

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Published on: March 14, 2021

Nuclear lipid signalling.

Robin F Irvine¹

¹Department of Pharmacology, Tennis Court Road, Cambridge CB2 1QJ, UK. rfi20@cam.ac.uk

Nature Reviews. Molecular Cell Biology

|May 3, 2003

Summary

This summary is machine-generated.

Eukaryotic cell nuclei contain distinct phospholipids, not just in the nuclear envelope. The inositol lipid cycle is a key part of this complex intranuclear lipid landscape.

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Area of Science:

Cell Biology
Molecular Biology
Biochemistry

Background:

Phospholipids are essential components of cell membranes.
Evidence over two decades indicates phospholipids exist within eukaryotic cell nuclei.
These intranuclear phospholipids differ from those in the nuclear envelope.

Purpose of the Study:

To summarize the current understanding of intranuclear phospholipids.
To highlight the phosphoinositide-phospholipase C cycle as a key pathway.
To suggest the existence of a broader, complex network of intranuclear lipids and functions.

Main Methods:

Literature review and synthesis of accumulated evidence.
Focus on characterized intranuclear lipid pathways.
Comparison with known cytoplasmic lipid signaling.

Main Results:

Phospholipids are demonstrably present within eukaryotic cell nuclei.
Inositol lipids and the phosphoinositide-phospholipase C cycle are well-characterized intranuclear lipid components.
The nuclear lipid environment is more complex than previously thought, involving numerous lipids and functions.

Conclusions:

Intranuclear phospholipids represent a distinct and functionally significant lipid pool.
The phosphoinositide-phospholipase C cycle is a major pathway for intranuclear lipid signaling.
Further research is warranted to elucidate the full spectrum of intranuclear lipids and their roles in cellular function.