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A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
Published on: February 7, 2015
[Importance of measurement of carotid artery distensibility]
1Interní klinika 2. lékarské fakulty UK a FN Motol, Praha.
Insights
Ultrasound assessment of carotid artery intima-media thickness (IMT) and distensibility (D) reveals poorer vascular function in diabetic patients with ischemic heart disease or cerebrovascular attack. These parameters may help differentiate stroke causes.
Area of Science:
- Cardiovascular Ultrasound
- Vascular Biology
- Diagnostic Imaging
Background:
- Major blood vessel affections can be non-invasively assessed using ultrasound.
- Carotid artery intima-media thickness (IMT) and distensibility (D) are key indicators of vascular health.
Purpose of the Study:
- To assess IMT and D in patients with ischemic heart disease (IHD) and cerebrovascular attack (CVA).
- To investigate the influence of type 2 diabetes and atrial fibrillation on these vascular parameters.
- To explore the correlation between IMT and D and their utility in differentiating stroke etiology.
Main Methods:
- Duplex sonography was employed in 234 patients (145 with IHD, 89 with CVA).
- Measurements included carotid artery IMT and D, with D calculated using Raneman's formula.
- Patient subgroups included those with type 2 diabetes (n=59) and atrial fibrillation (n=64).
Main Results:
- Diabetic subjects exhibited significantly poorer D in both IHD (0.16 vs. 0.20) and CVA (0.14 vs. 0.17) groups, correlating with IMT.
- Atrial fibrillation did not significantly affect IMT or D in IHD patients.
- CVA patients with atrial fibrillation showed better IMT (0.67 vs. 0.79 mm) and D (0.19 vs. 0.10) compared to those in sinus rhythm, suggesting potential for differentiating embolic vs. thrombotic causes.
Conclusions:
- IMT and D correlate indirectly, a relationship exacerbated by diabetes.
- Vascular parameters like IMT and D may aid in distinguishing the embolic versus thrombotic origins of cerebrovascular attacks.
- The study did not find superior informative value of D over IMT.
Abstract:
Affections of the structure of the major blood vessels can be assessed non-invasively by ultrasound. The authors assessed the thickness of the intima-media (IMT) and distensibility (D) of the carotid arteries in patients with ischaemic heart disease (IHD) and a cerebrovascular attack (CVA). Duplex sonography was used in 234 patients (145 patients with IHD and 89 patients with CVA) incl. assessment of IMT and D. 59 patients had type 2 diabetes and 64 had atrial fibrillations. D was evaluated according to Raneman's formula (mm/100 mm Hg). Diabetic subjects had a poorer D in the group with IHD (0.16 vs. 0.20, p < 0.05) as well as in the CVA group (0.14 vs. 0.17, p < 0.05) and the finding correlated with IMT. Insulin treatment as compared with PAD treatment did not influence D in a significant way (0.15 vs. 0.16, NS). Th presence of atrial fibrillation in patients with IHD did not affect the investigated parameters (IMT 0.72 vs. 0.74 mm, NS, D 0.19 vs. 0.18, NS). In patients with CVA, as compared with patients with a sinus rhythm, better IMT findings were recorded (0.67 mm vs. 0.79 mm, p < 0.05) and D (0.19 vs. 0.10, p < 0.05). The results indicate that IMT an D correlate indirectly and this is made more apparent by the presence of diabetes. In patients with CVA the different findings in relation to the presence of atrial fibrillation indicate the possibility to use these parameters to differentiate an embolic and thrombotic etiology of the attack. The results assembled by the authors do not support a better informative value of D as compared with IMT.
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