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Lessons for human diabetes from experimental mouse models
Rohit N Kulkarni1, Ariel Zisman
1Joslin Diabetes Center, One Joslin Place, Room 602, Boston, MA 02215, USA. Rohit.Kulkarni@joslin.harvard.edu
Current Diabetes Reports
|May 6, 2003
Abstract:
A precise knowledge of the defects underlying type 1 and type 2 diabetes is essential for designing appropriate therapeutic strategies. Because experiments in humans are limited, naturally occurring, and especially genetically engineered rodent models, have revolutionized research in diabetes. We review some of the models created recently and discuss their impact on human diabetes.