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Androgen levels in pregnant women decrease with increasing maternal age.

S M Carlsen1, G Jacobsen, K S Bjerve

  • 1Section of Endocrinology, Department of Medicine, St. Olav's Hospital. University Hospital of Trondheim, Trondheim, Norway.

Scandinavian Journal of Clinical and Laboratory Investigation
|May 6, 2003
PubMed
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Maternal androgen levels, including androstenedione and testosterone, decrease with advancing maternal age during pregnancy. This study found a negative association between maternal age and key androgen levels in uncomplicated pregnancies.

Area of Science:

  • Reproductive Endocrinology
  • Maternal-Fetal Medicine
  • Hormone Research

Background:

  • Investigating the influence of maternal age on hormonal profiles during pregnancy.
  • Understanding the physiological changes in uncomplicated pregnancies.

Purpose of the Study:

  • To determine if maternal age affects androgen levels in women with uncomplicated pregnancies.
  • To analyze the relationship between maternal age and specific androgens throughout gestation.

Main Methods:

  • Study involved 134 parous women in Norway and Sweden with uncomplicated pregnancies.
  • Measured maternal androstenedione, dehydroepiandrosterone sulfate, testosterone, and free testosterone index at 17 and 33 weeks gestation.
  • Controlled for parity, BMI, smoking, and fetal gender.

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Main Results:

  • Maternal androstenedione and testosterone levels showed a negative association with maternal age at both 17 and 33 weeks.
  • Dehydroepiandrosterone sulfate and free testosterone index were negatively associated with maternal age at 33 weeks only.
  • Adjustments for confounding factors did not alter these associations.

Conclusions:

  • Maternal androgen levels decline as maternal age increases during pregnancy.
  • The underlying mechanisms and clinical significance of this age-related decline in androgens are currently unknown.